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Diary of a CEO · 2025-08-18 · 1h 32m

Brain Experts WARNING: Watch This Before Using ChatGPT Again! (Shocking New Discovery)

Two brain experts warn Steven Bartlett that outsourcing thinking to ChatGPT may erode critical thinking and raise dementia risk.

Brain Experts WARNING: Watch This Before Using ChatGPT Again! (Shocking New Discovery)
The guest

Dr. Daniel Amen and Dr. Terry Sejnowski — Daniel Amen is a psychiatrist and brain-imaging pioneer who runs 11 clinics and has scanned more brains than almost anyone. Terry Sejnowski is a computational neuroscientist who co-invented the Boltzmann machine with Geoffrey Hinton.

The gist

Steven Bartlett sits down with psychiatrist Daniel Amen and computational neuroscientist Terry Sejnowski to examine how large language models like ChatGPT are affecting the human brain. They dissect a non-peer-reviewed MIT study showing a 47% drop in brain activity when people wrote with ChatGPT, debating whether AI builds 'cognitive debt' or, used interactively, can sharpen thinking. The conversation widens to AI companions like Grok's 'Annie', the loneliness epidemic, and the dangers of AI for developing young brains. The second half becomes a practical guide to brain health: exercise, sleep, the spacing effect, omega-3s, breathing, and avoiding artificial sweeteners. It closes with Bartlett resolving to 'do it the hard way' and think for himself when thinking matters.

Big reveals

  • MIT study found a 47% collapse in brain connectivity when people wrote with ChatGPT versus unaided, with memory scores plunging.
  • Amen stresses the alarming MIT study is NOT peer-reviewed, as the authors rushed it out because they felt it was too important to wait.
  • A meta-analysis of five studies linked SSRIs to a 75% increased risk of dementia.
  • Sejnowski calls Sam Altman's advice to stop saying 'thank you' to ChatGPT 'completely crazy' and says he wouldn't trust Altman with anything.
  • Amen compares sexy AI characters to a Vegas casino: they activate the limbic brain, shut down the prefrontal cortex, and exist for control and money.
  • Amen claims that if you don't believe in God you have three times the risk of depression.
  • A brand-new study found kids who took ADHD medication had larger prefrontal cortexes than unmedicated kids with ADHD.
  • Bartlett concludes his big hedge for the next decade is to 'go left when everyone goes right' and refrain from AI, doing the hard thinking himself.

Things worth remembering

  • In the MIT study, 83% of ChatGPT users couldn't correctly quote their own finished essay minutes later.
  • The 'cognitive debt' lingered: the AI group's brains stayed in low gear even after the tool was removed.
  • Alzheimer's onset is earliest in low-education populations and progressively later with more education.
  • Surveys show 19% of Americans have interacted with AI romantic partners, and 83% of Gen Z believe meaningful AI connection is possible.
  • Amen's '15-second breath': 4 seconds in, hold 1.5s, 8 seconds out, hold 1.5s, to boost parasympathetic tone and calm down fast.
  • Overuse of GPS navigation weakens the hippocampus by outsourcing spatial memory, potentially accelerating dementia onset.
  • In an experiment, mice taught to fear cherry-blossom scent passed that fear to their children and grandchildren epigenetically.
  • Depression doubles a woman's risk of Alzheimer's but quadruples a man's risk.
  • A JAMA Psychiatry study found a single sauna bath significantly helped depression, and frequent sauna users have the lowest Alzheimer's risk.
  • Amen's top three for brain health: exercise, daily optimism/gratitude, and omega-3 fatty acids (25% of brain cell membranes are omega-3).

Recommended in this episode

Books, products and media the guest or host genuinely endorsed here — with the buy link.

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Guest’s ownBook

Raising Mentally Strong Kids

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“I have a book called Raising Mentally Strong Kids, which I'm very happy about. And it starts with what kind of dad do I want to be” — Daniel Amen 00:56:32
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Change Your Brain Every Day

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“the incredible one that you wrote for parents called Raising Mentally Strong Kids. You've got your other book over there, Change Your Brain Every Day” — Steven Bartlett 01:25:31
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Healing Anxiety and Depression

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“And I wrote a book called Healing Anxiety and Depression and like here's the seven things I see as an imager.” — Daniel Amen 01:12:39
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The Deep Learning Revolution

Terry Sejnowski

“And I've got this book here from from Terry, which is The Deep Learning Revolution.” — Steven Bartlett 01:26:03
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Terry Sejnowski

“And one you wrote most recently called ChatGPT and The Future of AI. I'm going to link all of them below.” — Steven Bartlett 01:26:03
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